Also, visit HSP90 Central for details on AACR presentations related to ASTX's heat shock protein 90 inhibitor AT13387.
Find below the abstracts being presented by Astex Pharma at AACR on their clinical stage drugs SGI-110 (follow-on to DACOGEN aka decitabine) and AT13148, an AGC kinase inhibitor. Also, visit HSP90 Central for details on AACR presentations related to ASTX's heat shock protein 90 inhibitor AT13387.
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Astex Pharma will present a number of abstracts at next week's American Association for Cancer Research meeting. Among them may be a peak into the preclinical drug candidates next poised to enter the clinic in 2012. We may also get details at the March 27th Research and Development day. See the full abstracts below. You've probably read about the HSP90 inhibitor programs from companies like SNTA, ASTX, INFI, and MYRX here at BiotechDueDiligence. If you're interested in these promising but often troubled candidates, you'll want to check out the sister site dedicated to this class of drugs - HSP90 Inhibitors Central. Most recent updates over on that site are related to AUY922 and HSP990, being developed by Novartis $NVS and Vernalis LSE:$VER. 2012 is a big year for clinical data from HSP90 inhibitors, and you'll continue to find more updates on both of the sites, as well as detailed analysis for Chimera Research subscribers as we go through the year. The strong rebuke by the FDA and its Oncologic Drugs Advisory Committee (ODAC) to ASTX's attempt to gain approval for DACOGEN (decitabine) for elderly AML patients raised significant doubts as to whether the drug will gain approval in this indication in the US or Europe. If not, increased attention will shift to the rest of the company's pipeline. The slide deck from the companies joint analyst and investor R&D day in April 2011 is a good place to start. Find these presentations below and as always get more details on the ASTX research pages. Look forward to additional analysis of these programs here at BiotechDueDiligence and for Chimera Research Group subscribers.
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